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Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling

Paolo Cadinu, Kisha N. Sivanathan, Aditya Misra, Rosalind J. Xu, Davide Mangani, Evan Yang, Joseph M. Rone, Katherine Tooley, Yoon-Chul Kye, Lloyd Bod, Ludwig Geistlinger, Tyrone Lee, Noriaki Ono, Gang Wang, Liliana Sanmarco, Francisco J. Quintana, Ana C. Anderson, Vijay K. Kuchroo, Jeffrey R. Moffitt, Roni Nowarski. 2024

Cell

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Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

Jarret, A., R. Jackson, C. Duizer, M. E. Healy, J. Zhao, J. M. Rone, P. Bielecki, E. Sefik, M. Roulis, T. Rice, K. N. Sivanathan, T. Zhou, A. G. Solis, H. Honcharova-Biletska, K. Velez, S. Hartner, J. S. Low, R. Qu, M. R. de Zoete, N. W. Palm, A. M. Ring, A. Weber, A. E. Moor, Y. Kluger, R. Nowarski*, and R. A. Flavell*. 2020

Cell 180: 33-49 e22.

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Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense

Lai, N. Y., M. A. Musser, F. A. Pinho-Ribeiro, P. Baral, A. Jacobson, P. Ma, D. E. Potts, Z. Chen, D. Paik, S. Soualhi, Y. Yan, A. Misra, K. Goldstein, V. N. Lagomarsino, A. Nordstrom, K. N. Sivanathan, A. Wallrapp, V. K. Kuchroo, R. Nowarski, M. N. Starnbach, H. Shi, N. K. Surana, D. An, C. Wu, J. R. Huh, M. Rao, and I. M. Chiu. 2020

Cell 180: 33-49 e22.

The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier

Nowarski, R., R. Jackson, and R. A. Flavell. 2017

Cell 168: 362-375.

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Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

Nowarski, R., R. Jackson, N. Gagliani, M. R. de Zoete, N. W. Palm, W. Bailis, J. S. Low, C. C. Harman, M. Graham, E. Elinav, and R. A. Flavell. 2015

Cell 163: 1444-1456.

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Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

Nowarski, R., R. Jackson, N. Gagliani, M. R. de Zoete, N. W. Palm, W. Bailis, J. S. Low, C. C. Harman, M. Graham, E. Elinav, and R. A. Flavell. 2015

Cell 163: 1444-1456.

Graphical Abstract.jpg

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

Nowarski, R., R. Jackson, N. Gagliani, M. R. de Zoete, N. W. Palm, W. Bailis, J. S. Low, C. C. Harman, M. Graham, E. Elinav, and R. A. Flavell. 2015

Cell 163: 1444-1456.

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NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

Wlodarska, M., C. A. Thaiss, R. Nowarski, J. Henao-Mejia, J. P. Zhang, E. M. Brown, G. Frankel, M. Levy, M. N. Katz, W. M. Philbrick, E. Elinav, B. B. Finlay, and R. A. Flavell. 2014

Cell 156: 1045-1059.

Marta goblet.jpg

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

Nowarski, R., R. Jackson, N. Gagliani, M. R. de Zoete, N. W. Palm, W. Bailis, J. S. Low, C. C. Harman, M. Graham, E. Elinav, and R. A. Flavell. 2015

Cell 163: 1444-1456.

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Innate immune cells in inflammation and cancer

Nowarski, R., N. Gagliani, S. Huber, and R. A. Flavell. 2013

Cancer Immunology Research 1: 77-84.

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Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

Nowarski, R., R. Jackson, N. Gagliani, M. R. de Zoete, N. W. Palm, W. Bailis, J. S. Low, C. C. Harman, M. Graham, E. Elinav, and R. A. Flavell. 2015

Cell 163: 1444-1456.

Graphical Abstract.jpg

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

Elinav, E., R. Nowarski, C. A. Thaiss, B. Hu, C. Jin, and R. A. Flavell. 2013

Nature Reviews Cancer 13: 759-771.

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