We study the crosstalk between tissue and immune cells and the principles governing tissue regulation of immunity and inflammation

The cellular dynamics controlling the intestinal barrier in health and disease

Within the intestinal tissue, diverse immune and non-immune cells coordinate symbiotic relationships with the gut microbiota, as well as immunity against pathogenic infection. Using advanced genetic models and imaging platforms, we strive to identify the multicellular regulatory pathways controlling homeostatic immune responses in the gut and their breakdown during pathological inflammation.

The liver as a central regulator of immunity and inflammation

The liver is a key integrator of antibacterial responses and tolerance to circulating bacteria. By virtue of hosting the largest pool of tissue macrophages, the liver plays a central role in protecting the host against detrimental immune responses that lead to sepsis and organ failure. Our lab aims to elucidate the cellular crosstalk in the liver that governs protective and pathological immune responses to systemic infection.