We study the crosstalk between tissue and immune cells and the principles governing tissue regulation of innate immunity and inflammation
Cell circuits controlling the intestinal barrier in health and disease
Within the intestinal tissue, diverse immune and non-immune cells coordinate protective responses against pathogens and pathological inflammation. By studying immunometabolism, spatial organization and functional crosstalk, we strive to identify the multicellular regulatory pathways controlling immune tolerance in the gut and their breakdown during chronic inflammation.
The liver as a central regulator of immunity and inflammation
The liver is a key integrator of antibacterial responses and tolerance to circulating bacteria. By virtue of hosting the largest pool of tissue macrophages, the liver plays a central role in protecting the host against detrimental immune responses that lead to sepsis and organ failure. Our lab aims to elucidate the cellular crosstalk in the liver that governs protective and pathological immune responses to systemic infection.