We study the crosstalk between tissue and immune cells and how these interactions shape immunity and inflammation
Programming intestinal tolerance
Within the intestinal tissue, diverse immune and non-immune cells coordinate protective responses against pathogens and pathological inflammation. By studying immunometabolism, spatial organization and functional crosstalk, we strive to identify the multicellular regulatory pathways controlling immune tolerance in the gut and their breakdown during chronic inflammation.
Targeting systemic infection
If not contained by the immune system, bacterial or viral infection may cascade to devastating outcomes. The liver is a key integrator of antimicrobial responses and tolerance to circulating pathogens. By virtue of hosting the largest pool of tissue macrophages, the liver plays a central role in protecting the host against detrimental immune responses that lead to sepsis and organ failure. Our lab aims to elucidate the cellular crosstalk in the liver that governs protective and pathological immune responses to systemic infection.