One Inflammatory Disease at a Time
nflammation, while essential to preserve life, introduces difficult challenges to cellular communities
within tissues. Activation of inflammatory processes is associated with recruitment of potent immune cells and dramatic tissue remodeling that may regulate fundamental cellular functions across lineages and time scales. Successful resolution of inflammation requires that tissues regain the optimal homeostatic framework coordinating normal tissue function. However, inflammatory changes that cause prolonged dysregulation of the tissue molecular and cellular configuration may ultimately lead to organ dysfunction. Our lab strives to better understand the impact of inflammation on tissues, in particular macrophages and fibroblasts, with the goal of developing new therapeutic approaches for inflammatory bowel disease, sepsis and fibrosis.
Programming intestinal tolerance
Within the intestinal tissue, diverse immune and non-immune cells coordinate protective responses against pathogens and pathological inflammation. By studying immunometabolism, spatial organization and functional crosstalk, we strive to identify the multicellular regulatory pathways controlling immune tolerance in the gut and their breakdown during chronic inflammation.
Targeting systemic infection
If not contained by the immune system, bacterial or viral infection may cascade to devastating outcomes. The liver is a key integrator of antimicrobial responses and tolerance to circulating pathogens. By virtue of hosting the largest pool of tissue macrophages, the liver plays a central role in protecting the host against detrimental immune responses that lead to sepsis and organ failure. Our lab aims to elucidate the cellular crosstalk in the liver that governs protective and pathological immune responses to systemic infection.